CEYLON CINNAMON (CINNAMOMUM VERUM J. PRESL) – MEDICINAL PROPERTIES, USES, AND THERAPEUTIC POTENTIAL
DOI:
https://doi.org/10.58407/bht.2.26.14Keywords:
Ceylon cinnamon, bioactive compounds, anti-inflammatory activity, antioxidant activity, metabolic disorders, insulin sensitivity, phytochemistryAbstract
Purpose of the work. This article aims to analyse the health-promoting benefits of Ceylon cinnamon (Cinnamomum verum J. Presl) and evaluate its therapeutic value in contemporary medical and dietary contexts. It also discusses potential applications in preventing and supporting the treatment of metabolic, cardiovascular, neoplastic, neurodegenerative and infectious diseases, as well as digestive and skeletal system disorders. Additionally, the study assesses the safety of using cinnamon in various pharmaceutical and dietary forms.
Methodology. A review of the available scientific literature was conducted to obtain comprehensive information on the medicinal properties and potential applications of Ceylon cinnamon. The analysis included the following databases: PubMed Central, Scopus, ResearchGate, Web of Science, ScienceDirect, Ovid Technologies and Google Scholar. A total of 139 scientific articles and eight monographs were included in the review. The analysed materials comprised original research articles, systematic reviews, meta-analyses and experimental and clinical reports, which addressed the effects of the chemical compounds present in cinnamon on its therapeutic properties. Source selection was based on publication recency, methodological quality, and the clinical relevance of the reported findings.
Scientific novelty. This work offers a novel perspective on the health benefits of C. verum, highlighting its potential as an adjunctive therapy for cancer, metabolic, infectious and neurodegenerative diseases. The article presents research findings that indicate the broad spectrum of activity of the bioactive compounds found in cinnamon, and their potential application in clinical practice. Particular attention is given to the molecular mechanisms of phytochemical action and the use of modern technologies to enhance bioavailability and therapeutic efficacy, such as nanoparticles and mucoadhesive gels. Combining botanical, pharmacological, and clinical knowledge using an interdisciplinary approach enabled a holistic assessment of the therapeutic potential of Ceylon cinnamon.
Conclusions. Cinnamon has been used in Asian cuisine for several thousand years, not only as a spice, but also as a medicinal ingredient. It is characterised by its rich phytochemistry and wide range of health-promoting effects. C. verum alleviates disorders of the digestive, urinary and skeletal systems, and exhibits strong antioxidant and anti-inflammatory properties. Available data suggest that it may support the treatment of numerous diseases, including cancer, due to its antioxidant content and ability to modulate inflammatory processes. Its documented biological activities – anti-inflammatory, antiviral, antibacterial, antiparasitic, anti-obesity and antineurodegenerative – have a beneficial impact on human health. Compounds present in cinnamon essential oils improve tissue insulin sensitivity, reduce blood glucose and lipid levels, and inhibit the development of neoplastic and infectious processes. The use of modern delivery systems for bioactive substances, such as nanoparticles and mucoadhesive gels, can significantly increase the bioavailability and therapeutic efficacy of cinnamon while reducing its toxicity to normal cells. Furthermore, taking cinnamon supplements at doses of 1-6 g per day has been shown to have the most favourable health effects. Products derived from the bark, leaves and roots of the cinnamon tree are used in herbal medicine, cosmetology and the food and beverage industry.
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References
Abraham, K., Wöhrlin, F., Lindtner, O., Heinemeyer, G., & Lampen, A. (2010). Toxicology and risk assessment of coumarin: focus on human data. Molecular nutrition & food research, 54(2), 228–239. https://doi.org/10.1002/mnfr.200900281
Abu El Ezz, N. M. T., Khalil, F. A. M., & Shaapan, R. M. (2011). Therapeutic effect of onion (Allium cepa) and cinnamon (Cinnamomum zeylanicum) oils on cryptosporidiosis in experimentally infected mice. Global Veterinaria, 7(2), 179–183. https://www.researchgate.net/publication/286031888
Afrin, F., Chouhan, G., Islamuddin, M., Want, M. Y., Ozbak, H. A., & Hemeg, H. A. (2019). Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo. PLoS Neglected Tropical Diseases, 13(5), e0007227. https://doi.org/10.1371/journal.pntd.0007227
Aggarwal, S., Bhadana, K., Singh, B., Rawat, M., Mohammad, T., Al-Keridis, L. A., Alshammari, N., Hassan, A. I., & Das, S. N. (2022). Cinnamomum zeylanicum extract and its bioactive component cinnamaldehyde show anti-tumor effects via inhibition of multiple cellular pathways. Frontiers in Pharmacology, 13, 918479. https://doi.org/10.3389/fphar.2022.918479
Ahmad, M. G., Chakravarthi, S., Bhagwart, P., Daharia, A., Sarsan, S., Sudhakarmeesala, Arora, N., Guria, T., Matta, Y., & Kumar, A. (2025). Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing Eugenia caryophyllata and Cinnamomum verum for treatment of oral cancer. Journal of Neonatal Surgery, 14(12s), 677–683. https://doi.org/10.52783/jns.v14.3297
Ahmadi, A., Naziri, M., Fallahpour, F., Gholami, K., Arabpour, J., Pezeshgare, F., Akbarzadeh, D., Ansari, A., Sabri, H., & Deravi, N. (2022). Therapeutic potential of cinnamon for neurological disorders: A mini-review. Neurology Asia, 27(1), 1–17. https://doi.org/10.54029/2022uxk
Alanazi, A. D., & Almohammed, H. I. (2022). Therapeutic potential and safety of the Cinnamomum zeylanicum methanolic extract against chronic Toxoplasma gondii infection in mice. Frontiers in Cellular and Infection Microbiology, 12, 900046. https://doi.org/10.3389/fcimb.2022.900046
Alanazi, M. M. (2024). Utilizing Cinnamomum verum extract for green synthesis of silver nanoparticles: Exploring optical properties, morphology, and potential applications. Journal of King Saud University – Science, 36(8), 103312. https://doi.org/10.1016/j.jksus.2024.103312
Allen, C. M., & Blozis, G. G. (1988). Oral mucosal reactions to cinnamon-flavored chewing gum. Journal of the American Dental Association (1939), 116(6), 664–667. https://doi.org/10.14219/jada.archive.1988.0003
Anderson, M., Hrivnak, W., Prak, K., & Stockert, A. (2024). Effects of cinnamon on cancer prevention and progression. Qeios, 1–15. https://doi.org/10.32388/EVIQDP
Angelopoulou, E., Nath Paudel, Y., Piperi, C., & Mishra, A. (2021). Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities. Journal of biochemical and molecular toxicology, e22711. Advance online publication. https://doi.org/10.1002/jbt.22711
Babu, P. V., Liu, D., & Gilbert, E. R. (2013). Recent advances in understanding the anti-diabetic actions of dietary flavonoids. The Journal of Nutritional Biochemistry, 24(11), 1777–1789. https://doi.org/10.1016/j.jnutbio.2013.06.003
Badger-Emeka, L., Emeka, P. M., Thirugnanasambantham, K., & Ibrahim, H. I. M. (2020). Anti-allergic potential of cinnamaldehyde via the inhibitory effect of histidine decarboxylase (HDC) producing Klebsiella pneumoniae. Molecules, 25(23), 5580. https://doi.org/10.3390/molecules25235580
Barceloux, D. G. (2009). Cinnamon (Cinnamomum species). Disease-a-Month, 55(6), 327–335. https://doi.org/10.1016/j.disamonth.2009.03.003
Behbahani, B. A., Falah, F., Lavi Arab, F., Vasiee, M., & Yazdi, F. T. (2020). Chemical composition and antioxidant, antimicrobial, and antiproliferative activities of Cinnamomum zeylanicum bark essential oil. Evidence-Based Complementary and Alternative Medicine, 2020, 5190603. https://doi.org/10.1155/2020/5190603
Bellassoued, K., Ghrab, F., Hamed, H., Kallel, R., van Pelt, J., Lahyani, A., Ayadi, F. M., & El Feki, A. (2019). Protective effect of essential oil of Cinnamomum verum bark on hepatic and renal toxicity induced by carbon tetrachloride in rats. Applied Physiology, Nutrition, and Metabolism, 44(6), 606–618. https://doi.org/10.1139/apnm-2018-0246
Blevins, S. M., Leyva, M. J., Brown, J., Wright, J., Scofield, R. H., & Aston, C. E. (2007). Effect of cinnamon on glucose and lipid levels in non–insulin-dependent type 2 diabetes. Diabetes Care, 30(9), 2236–2237. https://doi.org/10.2337/dc07-0098
Campbell, T. M., Neems, R., & Moore, J. (2008). Severe exacerbation of rosacea induced by cinnamon supplements. Journal of Drugs in Dermatology, 7(6), 586–587. https://pubmed.ncbi.nlm.nih.gov/18561592
Caserta, S., Genovese, C., Cicero, N., Gangemi, S., & Allegra, A. (2023). The anti-cancer effect of cinnamon aqueous extract: A focus on hematological malignancies. Life (Basel, Switzerland), 13(5), 1176. https://doi.org/10.3390/life13051176
Chanderbali, A. S., van der Werff, H., & Renner, S. S. (2001). Phylogeny and historical biogeography of Lauraceae: Evidence from the chloroplast and nuclear genomes. Annals of the Missouri Botanical Garden, 88(1), 104–134. https://doi.org/10.2307/2666133
Cheng, B. Q., & Yu, X. J. (1993). Cultivation of Ceylon cinnamon and chemical components of its essential oil. Zhongcaoyao, 14, 134–137.
Christiany, C., Sudrajat, S. E., & Rahayu, I. (2021). The potency of Cinnamomum zeylanicum to prevent diseases: A review. Eureka Herba Indonesia, 2(1), 49–58. https://doi.org/10.37275/ehi.v2i1.11
Das, S. (2020). Natural therapeutics for urinary tract infections – A review. Future Journal of Pharmaceutical Sciences, 6, 64. https://doi.org/10.1186/s43094-020-00086-2
de Souza Gouveia Moreira, L., de Souza da Costa Brum, I., de Vargas Reis, D. C. M., Trugilho, L., Chermut, T. R., Esgalhado, M., Cardozo, L. F. M. F., Stenvinkel, P., Shiels, P. G., & Mafra, D. (2023). Cinnamon: An aromatic condiment applicable to chronic kidney disease. Kidney Research and Clinical Practice, 42(1), 4–26. https://doi.org/10.23876/j.krcp.22.111
del Bosque-Plata, L., & Gragnoli, C. (2025). Cinnamon treatment shows promise for glycemic control but may cause adverse effects in some people. Clinical Nutrition Open Science, 59, 184–188. https://doi.org/10.1016/j.nutos.2025.01.003
Deng R. (2012). A review of the hypoglycemic effects of five commonly used herbal food supplements. Recent patents on food, nutrition & agriculture, 4(1), 50–60. https://doi.org/10.2174/2212798411204010050
Dhore, M. R., & Jha, A. R. (2019). Antimicrobial activity of Allium cepa and Cinnamomum zeylanicum against common bacteria causing urinary tract infections: In vitro study. International Journal of Basic & Clinical Pharmacology, 8(6), 1185–1191. http://dx.doi.org/10.18203/2319-2003.ijbcp20192182
El-Baroty, G. S., Abd El-Baky, H. H., Farag, R. S., & Saleh, M. A. (2010). Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. African Journal of Biochemistry Research, 4(6), 167–174.
El-Saber Batiha, G., Beshbishy, A. M., Guswanto, A., Nugraha, A., Munkhjargal, T., Abdel-Daim, M. M., Mosqueda, J., & Igarashi, I. (2020). Phytochemical characterization and chemotherapeutic potential of Cinnamomum verum extracts on the multiplication of protozoan parasites in vitro and in vivo. Molecules, 25(4), 996. https://doi.org/10.3390/molecules25040996
Fabbri, J., Maggiore, M. A., Pensel, P. E., Denegri, G. M., & Elissondo, M. C. (2020). In vitro efficacy study of Cinnamomum zeylanicum essential oil and cinnamaldehyde against the larval stage of Echinococcus granulosus. Experimental Parasitology, 214, 107904. https://doi.org/10.1016/j.exppara.2020.107904
Fajar, A., Ammar, G. A., Hamzah, M., Manurung, R., & Adbuh, M. Y. (2019). Effect of tree age on the yield, productivity, and chemical composition of essential oil from Cinnamomum burmannii. Current Research on Biosciences and Biotechnology, 1(1), 17–22. https://doi.org/10.5614/crbb.2019.1.1
Farrell, K. T. (1985). Spices, condiments, and seasonings (2nd ed.). Aspen Publishers.
Fichi, G., Flamini, G., Zaralli, L. J., & Perrucci, S. (2007). Efficacy of an essential oil of Cinnamomum zeylanicum against Psoroptes cuniculi. Phytomedicine: international journal of phytotherapy and phytopharmacology, 14(2-3), 227–231. https://doi.org/10.1016/j.phymed.2006.01.004
Frydman-Marom, A., Levin, A., Farfara, D., Benromano, T., Scherzer-Attali, R., Peled, S., Vassar, R., Segal, D., Gazit, E., Frenkel, D., & Ovadia, M. (2011). Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models. PLoS ONE, 6(1), e16564. https://doi.org/10.1371/journal.pone.0016564
Gannon, N. P., Schnuck, J. K., Mermier, C. M., Conn, C. A., & Vaughan, R. A. (2015). trans-Cinnamaldehyde stimulates mitochondrial biogenesis through PGC‑1α and PPARβ/δ leading to enhanced GLUT4 expression. Biochimie, 119, 45–51. https://doi.org/10.1016/j.biochi.2015.10.001
Garcia-Abujeta, J. L., de Larramendi, C. H., Berna, J. P., & Palomino, E. M. (2005). Mud bath dermatitis due to cinnamon oil. Contact dermatitis, 52(4), 234. https://doi.org/10.1111/j.0105-1873.2005.0566h.x
Georgakopoulou E. A. (2010). Cinnamon contact stomatitis. Journal of dermatological case reports, 4(2), 28–29. https://doi.org/10.3315/jdcr.2010.1047
George, T. M., Prabha, M., Patil, M. S., Sakshi, S., & Shifa. (2024). Investigation of anticancer properties of cinnamon phytochemicals on protein expression in glioblastoma multiforme cell lines (U87‑MG). IP Indian Journal of Neurosciences, 10(1), 30–39. https://doi.org/10.18231/j.ijn.2024.006
Ghosh, D. (2024). Modern medicinal use of cinnamon. Journal of Nutritional Disorders & Therapy, 14(3), 298. https://doi.org/10.35248/2161-0509.24.14.298
Goel, B., & Mishra, S. (2020). Medicinal and nutritional perspective of cinnamon: A mini-review. European Journal of Medicinal Plants, 31(3), 10–16. https://doi.org/10.9734/ejmp/2020/v31i330218
Grant-Alfieri, A., Schaechter, J., & Lipshultz, S. E. (2013). Ingesting and aspirating dry cinnamon by children and adolescents: the "cinnamon challenge". Pediatrics, 131(5), 833–835. https://doi.org/10.1542/peds.2012-3418
Gruenwald, J., Freder, J., & Armbruester, N. (2010). Cinnamon and health. Food Science and Nutrition, 50(9), 822–834. https://doi.org/10.1080/10408390902773052
Gu, D. T., Tung, T. H., Jiesisibieke, Z. L., Chien, C. W., & Liu, W. Y. (2021). Safety of cinnamon: An umbrella review of meta-analyses and systematic reviews of randomized clinical trials. Frontiers in Pharmacology, 12, 790901. https://doi.org/10.3389/fphar.2021.790901
Guan, X., Su, M. C., Zhao, R. B., Ouyang, H. M., Dong, X. D., Pei, Q., Lu, J., Li, Z. F., Zhang, C. R., & Yang, T.-H. (2016). Cinnamon effectively inhibits the activity of leukemia stem cells. Genetics and Molecular Research, 15(3), 10.4238/gmr.15037662. https://doi.org/10.4238/gmr.15037662
Gurel, A., Turk, A., Aydin, H., Genc, F., & Yalcin, Y. (2022). Cinnamon’s effect on apoptosis, inflammation and TRPM2 channels in methotrexate‑induced renal damage. International Journal of Advanced Research in Medicine, 4(2), 6–10. https://doi.org/10.22271/27069567.2022.v4.i2a.387
Hadi, A., Campbell, M. S., Hassani, B., Pourmasoumi, M., Salehi-Sahlabadi, A., & Hosseini, S. A. (2020). The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials. Clinical nutrition ESPEN, 36, 10–16. https://doi.org/10.1016/j.clnesp.2020.01.002
Hagenlocher, Y., Bergheim, I., Zacheja, S., Schäffer, M., Bischoff, S. C., & Lorentz, A. (2013). Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells. Allergy, 68(4), 490–497. https://doi.org/10.1111/all.12122
Hajimonfarednejad, M., Ostovar, M., Raee, M. J., Hashempur, M. H., Mayer, J. G., & Heydari, M. (2019). Cinnamon: A systematic review of adverse events. Clinical nutrition (Edinburgh, Scotland), 38(2), 594–602. https://doi.org/10.1016/j.clnu.2018.03.013
Han, X., & Parker, T. L. (2017). Antiinflammatory activity of cinnamon (Cinnamomum zeylanicum) bark essential oil in a human skin disease model. Phytotherapy research: PTR, 31(7), 1034–1038. https://doi.org/10.1002/ptr.5822
Hatte, S., Mandave, P., & Jadhav, A. (2025). Evaluation of anticancer activity of Cinnamomum zeylanicum against blood cancer cell line. Journal of Microbiology, Biotechnology and Food Sciences, 14(4), e11729. https://doi.org/10.55251/jmbfs.11729
Hong, S., Cha, K. H., Park, J. H., Jung, D. S., Choi, J. H., Yoo, G., & Nho, C. W. (2022). Cinnamic acid suppresses bone loss via induction of osteoblast differentiation with alteration of gut microbiota. The Journal of Nutritional Biochemistry, 101, 108900. https://doi.org/10.1016/j.jnutbio.2021.108900
Horby, P., Lim, W. S., Emberson, J. R., Mafham, M., Bell, J. L., Linsell, L., Staplin, N., Brightling, C., Ustianowski, A., Elmahi, E., Prudon, B., Green, C., Felton, T., Chadwick, D., Rege, K., Fegan, C., Chappell, L. C., Faust, S. N., Jaki, T., Jeffery, K., Montgomery, A., Rowan, K., Juszczak, E., Baillie, J. K., Haynes, R., & Landray, M. J. (2020). Dexamethasone in hospitalized patients with Covid‑19. The New England Journal of Medicine, 384(8), 693–704. https://doi.org/10.1056/NEJMoa2021436
Huang, B., Yuan, H. D., Kim, D. Y., Quan, H. Y., & Chung, S. H. (2011). Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated receptor-γ (PPARγ) and AMP-activated protein kinase (AMPK) pathways. Journal of Agricultural and Food Chemistry, 59(8), 3666–3673. https://doi.org/10.1021/jf104814t
Hwang, S. H., Choi, Y. G., Jeong, M. Y., Hong, Y. M., Lee, J. H., & Lim, S. (2009). Microarray analysis of gene expression profile by treatment of Cinnamomi ramulus in lipopolysaccharide-stimulated BV‑2 cells. Gene, 443(1–2), 83–90. https://doi.org/10.1016/j.gene.2009.04.024
Jachowicz, A., & Dybova‑Jachowicz, S. (2003). Paleobotanika. Wydawnictwo Uniwersytetu Śląskiego, Katowice.
Javed, I., Faisal, I., Zia Ur, R., Khan, M. Z., Muhammad, F., Aslam, B., Ahmad, M., & Shahzadi, A. (2012). Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits. Pakistan Journal of Pharmaceutical Sciences, 25(1), 141–147.
Jayaprakasha, G. K., Rao, L. J., & Sakariah, K. K. (2002). Chemical composition of volatile oil from Cinnamomum zeylanicum buds. Zeitschrift fur Naturforschung. C, Journal of biosciences, 57(11-12), 990–993. https://doi.org/10.1515/znc-2002-11-1206
Jensen‑Jarolim, E., Roth‑Walter, F., Leitner, E., Buchleitner, S., Vogelsang, H., & Kinaciyan, T. (2016). Prime and boost aerosol exposure via fog machine or shisha smoke followed by cinnamon hypersensitivity and anaphylaxis to spiced food. World Allergy Organization Journal, 9(4), 1–7. https://doi.org/10.1186/s40413-016-0091-6
Joshi, K., Awati, S., Desai, A., Halakatti, P., Irappanavar, S., Vijapur, L., & Metre, A. (2025). Cinnamomum verum: Biogenic synthesis of silver nanoparticles and in vitro anticancer activity on A-431 cell lines. Hacettepe University Journal of the Faculty of Pharmacy, 45(2), 131–145. https://doi.org/10.52794/hujpharm.1625482
Kaławaj, K., & Lemieszek, M. K. (2015). Prozdrowotne właściwości cynamonu. Medycyna Ogólna i Nauki o Zdrowiu, 21(3), 328–331. https://doi.org/10.5604/20834543.1165362
Kang, H., Park, S. H., Yun, J. M., Nam, T. G., Kim, Y. E., & Kim, D. O. (2014). Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity. BMC Complementary and Alternative Medicine, 14, 90. https://doi.org/10.1186/1472-6882-14-90
Kaul, P. N., Bhattacharya, A. K., Rajeswara Rao, B. R., Syamasundar, K. V., & Ramesh, S. (2003). Volatile constituents of essential oils isolated from different parts of cinnamon (Cinnamomum zeylanicum Blume). Journal of the Science of Food and Agriculture, 83, 53–55. https://doi.org/10.1002/jsfa.1277
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., & Anderson, R. A. (2003). Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes care, 26(12), 3215–3218. https://doi.org/10.2337/diacare.26.12.3215
Khan, M. F., Charbaji, A. M. Y., Baabbad, A. A., Almoutiri, N. D., & Wadaan, M. A. M. (2023). Investigating the role of Cinnamomum verum in zebrafish swim bladder development and anti‑cancer activity in human lung cancer cell lines. Arabian Journal of Chemistry, 16(12), 105361. https://doi.org/10.1016/j.arabjc.2023.105361
Khare, P., Jagtap, S., Jain, Y., Baboota, R. K., Mangal, P., & Boparai, R. K. (2016). Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice. Biofactors, 42(2), 201–211. https://doi.org/10.1002/biof.1265
Khasanavis, S., & Pahan, K. (2014). Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson’s disease. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology, 9(4), 569–581. https://doi.org/10.1007/s11481-014-9552-2
Khedkar, S., & Khan, M. A. (2023). Aqueous extract of cinnamon (Cinnamomum spp.): Role in cancer and inflammation. Evidence-Based Complementary and Alternative Medicine, 2023, 5467342. https://doi.org/10.1155/2023/5467342
Khoshnevisan, K., Alipanah, H., Baharifar, H., Ranjbar, N., & Osanloo, M. (2022). Chitosan nanoparticles containing Cinnamomum verum J. Presl essential oil and cinnamaldehyde: Preparation, characterization and anticancer effects against melanoma and breast cancer cells. Traditional and Integrative Medicine, 7(1), 1–12. https://doi.org/10.18502/tim.v7i1.9058
Kim, M. S., & Kim, J. Y. (2017). Intestinal anti-inflammatory effects of cinnamon extracts in a co-culture model of intestinal epithelial Caco-2 cells and RAW264.7 macrophages. Applied Biological Chemistry, 60(5), 553–561. https://doi.org/10.1007/s13765-017-0311-y
Kohlmünzer, S. (2007). Farmakognozja. Podręcznik dla studentów farmacji. Wydawnictwo Lekarskie PZWL, Warszawa.
Kornaś, J., & Medwecka-Kornaś, A. (2002). Geografia roślin. Warszawa.
Kowalska, J., Tyburski, J., Matysiak, K., Jakubowska, M., Łukaszyk, J., & Krzymińska, J. (2021). Cinnamon as a Useful Preventive Substance for the Care of Human and Plant Health. Molecules (Basel, Switzerland), 26(17), 5299. https://doi.org/10.3390/molecules26175299
Kubatka, P., Kello, M., Kajo, K., Samec, M., Jasek, K., Vybohova, D., Uramova, S., Liskova, A., Sadlonova, V., Koklesova, L., Murin, R., Adamkov, M., Smejkal, K., Svajdlenka, E., Solar, P., Samuel, S. M., Kassayova, M., Kwon, T. K., Zubor, P., Pec, M., Danko, J., Büsselberg, D., & Mojzis, J. (2020). Chemopreventive and therapeutic efficacy of Cinnamomum zeylanicum L. bark in experimental breast carcinoma: Mechanistic in vivo and in vitro analyses. Molecules, 25(6), 1399. https://doi.org/10.3390/molecules25061399
Kutbi, E. H., Sohouli, M. H., Fatahi, S., Lari, A., Shidfar, F., Aljhdali, M. M., Alhoshan, F. M., Elahi, S. S., Almusa, A. A., & Abu‑Zaid, A. (2021). The beneficial effects of cinnamon among patients with metabolic diseases: A systematic review and dose-response meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 62(22), 6113–6131. https://doi.org/10.1080/10408398.2021.1896473
Lee, R., & Balick, M. J. (2005). Sweet wood – Cinnamon and its importance as a spice and medicine. Explore: The Journal of Science and Healing, 1(1), 61–64. https://doi.org/10.1016/j.explore.2004.10.011
Lee, S. H., Lee, S. Y., Son, D. J., Lee, H., Yoo, H. S., Song, S., Oh, K. W., Han, D. C., Kwon, B. M., & Hong, J. T. (2005). Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF‑κB activation in RAW 264.7 cells. Biochemical Pharmacology, 69(5), 791–799. https://doi.org/10.1016/j.bcp.2004.11.013
Li, C.-Y., Liao, L.-J., Yang, S.-X., Wang, L.-Y., Chen, H., Luo, P., Huang, G.-R., & Huang, Y.-Q. (2024). Cinnamaldehyde: An effective component of Cinnamomum cassia inhibiting Helicobacter pylori. Journal of Ethnopharmacology, 330, 118222. https://doi.org/10.1016/j.jep.2024.118222
Li, Y.-G., Kong, D.-X., & Wu, H. (2013). Analysis and evaluation of essential oil components of cinnamon barks using GC–MS and FTIR spectroscopy. Industrial Crops and Products, 41, 269–278. https://doi.org/10.1016/j.indcrop.2012.04.056
Liyanage, N. M. N., Bandusekara, B. S., Kanchanamala, R. W. M. K., Hathurusinghe, H. A. B. M., Rathnayaka, A. M. R. W. S. D., Gamini Pushpakumara, D. K. N., Samita, S., Wijesinghe, K. G. G., Jayasinghe, G. G., Liyanage, W. K., & Bandaranayake, P. C. G. (2021). Identification of superior Cinnamomum zeylanicum Blume germplasm for future true cinnamon breeding in the world. Journal of Food Composition and Analysis, 96, 103747. https://doi.org/10.1016/j.jfca.2020.103747
Mallavarapu, G. R., & Rajeswara Rao, B. R. (2007). Chemical constituents and uses of Cinnamomum zeylanicum Blume. In: L. Jitrovetz, N. X. Dung, & V. K. Varshney (Eds.), Aromatic plants from Asia: Their chemistry and application in food and therapy (pp. 49–75). Har Krishan Bhalla & Sons, Dehradun, India.
Mallavarapu, G. R., Ramesh, S., Chandrasekhara, R. S., Rajeswara Rao, B. R., Kaul, P. N., & Bhattacharya, A. K. (1995). Investigation of the essential oil of cinnamon leaf grown at Bangalore and Hyderabad. Flavour and Fragrance Journal, 10(4), 239–242. https://doi.org/10.1002/ffj.2730100403
Malsawmtluangi, L., Nautiyal, B. P., Hazarika, T., Chauhan, R. S., & Tava, A. (2016). Essential oil composition of bark and leaves of Cinnamomum verum Bertch & Presl from Mizoram, North East India. Journal of Essential Oil Research, 28(6), 551–556. https://doi.org/10.1080/10412905.2016.1167131
Mariappan, P. M., Sabesan, G., Koilpillai, B., Janakiraman, S., & Sharma, N. K. (2013). Chemical characterisation and antifungal activity of methanolic extract of Cinnamomum verum J. Presl bark against Malassezia spp. Pharmacognosy Journal, 5(5), 197–204. https://doi.org/10.1016/j.phcgj.2013.09.001
Maruthamuthu, R., & Ramanathan, K. (2016). Phytochemical analysis of bark extract of Cinnamomum verum: A medicinal herb used for the treatment of coronary heart disease in Malayali tribes, Pachamalai hills, Tamil Nadu, India. International Journal of Pharmacognosy and Phytochemical Research, 8(7), 1218–1222.
Mehrpouri, M., Hamidpour, R., & Hamidpour, M. (2020). Cinnamon inhibits platelet function and improves cardiovascular system. Journal of Medicinal Plants, 19(73), 1–11. https://doi.org/10.29252/jmp.1.73.1
Mohammadabadi, T., & Jain, R. (2024). Cinnamon: A nutraceutical supplement for the cardiovascular system. Archives of Medical Science, 9, 72–81. https://doi.org/10.5114/amsad/184245
Mohanty, D., Padhee, S., Priyadarshini, A., Champati, B. B., Das, P. K., Jena, S., Sahoo, A., Panda, P. C., Nayak, S., & Ray, A. (2024). Elucidating the anti-cancer potential of Cinnamomum tamala essential oil against non-small cell lung cancer: A multifaceted approach involving GC‑MS profiling, network pharmacology, and molecular dynamics simulations. Heliyon, 10(6), e28026. https://doi.org/10.1016/j.heliyon.2024.e28026
Mohanty, D., Padhee, S., Priyadarshini, A., Kerry, R. G., Dash, B., Sahoo, A., Jena, S., Panda, P.-C., Khan, H. A., Nayak, S., & Ray, A. (2025). Integrative approach to decipher pharmacological mechanism of Cinnamomum zeylanicum essential oil in prostate cancer. Medical oncology (Northwood, London, England), 42(4), 100. https://doi.org/10.1007/s12032-025-02665-w
Momtaz, S., Hassani, S., Khan, F., Ziaee, M., & Abdollahi, M. (2018). Cinnamon, a promising prospect towards Alzheimer's disease. Pharmacological research, 130, 241–258. https://doi.org/10.1016/j.phrs.2017.12.011
Moragoda, J. (2021). Cinnamomum zeylanicum: Continuing voyages of discovery. In: M. McWilliams (Ed.), Proceedings of the Oxford Symposium on Food and Cookery, 2020 (pp. 250–262). Prospect Books. https://doi.org/10.1016/j.ijgfs.2023.100858
Mota, A. P. P., Campelo, T. A., & Frota, C. C. (2019). Evaluation of the antimicrobial activity of Cinnamomum zeylanicum essential oil and trans-cinnamaldehyde against resistant Mycobacterium tuberculosis. Bioscience Journal, 35(1), 296–306. http://dx.doi.org/10.14393/BJ-v35n1a2019-41710
Muhammad, D. R. A., Tuenter, E., Patria, G. D., Foubert, K., Pieters, L., & Dewettinck, K. (2021). Phytochemical composition and antioxidant activity of Cinnamomum burmannii Blume extracts and their potential application in white chocolate. Food Chemistry, 340, 127983. https://doi.org/10.1016/j.foodchem.2020.127983
Narayana, S. K. K., Gopi, D. K., Rubeena, M., & Parameswaran, S. R. (2019). Macro-micro-morphological diagnosis of leaves of two species of Cinnamomum (C. sulphuratum and C. verum) used as resource of bay leaf. AYU: An International Quarterly Journal of Research in Ayurveda, 40(3), 196–203. https://doi.org/10.4103/ayu.AYU_194_17
Narayanan, A., Muyyarikkandy, M. S., Mooyottu, S., Venkitanarayanan, K., & Amalaradjou, M. A. R. (2017). Oral supplementation of trans-cinnamaldehyde reduces uropathogenic Escherichia coli colonization in a mouse model. Letters in Applied Microbiology, 64(3), 192–197. https://doi.org/10.1111/lam.12713
Narayanankutty, A., Kunnath, K., Alfarhan, A., Rajagopal, R., & Ramesh, V. (2021). Chemical composition of Cinnamomum verum leaf and flower essential oils and analysis of their antibacterial, insecticidal, and larvicidal properties. Molecules, 26(20), 6303. https://doi.org/10.3390/molecules26206303
Nayak, I. N., Rajasekhar, C. H., & Jetti, R. (2017). Anti-atherosclerotic potential of aqueous extract of Cinnamomum zeylanicum bark against glucocorticoid-induced atherosclerosis in Wistar rats. Journal of Clinical and Diagnostic Research, 11(5), 19–23. https://doi.org/10.7860/JCDR/2017/23910.9864
Oketch-Rabah, H. A., Marles, R. J., & Brinckmann, J. A. (2018). Cinnamon and Cassia Nomenclature Confusion: A Challenge to the Applicability of Clinical Data. Clinical pharmacology and therapeutics, 104(3), 435–445. https://doi.org/10.1002/cpt.1162
Ose, R., Tu, J., Schink, A., Maxeiner, J., Schuster, P., Lucas, K., Saloga, J., & Bellinghausen, I. (2019). Cinnamon extract inhibits allergen-specific immune responses in human and murine allergy models. Clinical and Experimental Allergy, 50(1), 41–50. https://doi.org/10.1111/cea.13507
Pandey, A., & Tripathi, S. (2018). Concept of standardization, extraction and pre-phytochemical screening strategies for herbal drug. Journal of Pharmacognosy and Phytochemistry, 2(5), 115–119.
Parry, J. W. (1969). Spices: Morphology, histology, chemistry (Vol. II). Chemical Publishing. https://archive.org/details/parry-1969-spices/page/n181/mode/2up
Pathak, R., & Sharma, H. (2021). A review on medicinal uses of Cinnamomum verum (cinnamon). Journal of Drug Delivery and Therapeutics, 11(6‑S), 161–166. http://dx.doi.org/10.22270/jddt.v11i6-S.5145
Peterson, D. W., George, R. C., Scaramozzino, F., Lapointe, N. E., Anderson, R. A., Graves, D. J., & Lew, J. (2009). Cinnamon extract inhibits tau aggregation associated with Alzheimer’s disease in vitro. Journal of Alzheimer’s Disease, 17(3), 585–597. https://doi.org/10.3233/JAD-2009-1083
Pitton Rissardo, J., McGarry, A., Shi, Y., Fornari Caprara, A. L., & Kannarkat, G. T. (2025). Alpha-Synuclein Neurobiology in Parkinson’s Disease: A Comprehensive Review of Its Role, Mechanisms, and Therapeutic Perspectives. Brain Sciences, 15(12), 1260. https://doi.org/10.3390/brainsci15121260
Prabhuji, S. K., Rao, G. P., Pande, S., Richa, Srivastava, G. K., & Srivastava, A. K. (2021). Cinnamomum species: Spices of immense medicinal and pharmacological values. Medicinal Plants, 13(2), 202–220. https://doi.org/10.5958/0975-6892.2021.00024.1
Pratibha, Yadav, S. S., Bhandari, U., & Naik, G. (2018). Antioxidant properties and phytochemical screening of commercial cinnamon bark. European Journal of Biomedical and Pharmaceutical Sciences, 5(2), 964–970.
Qi, L., Mao, H., Lu, X., Shi, T., & Wang, J. (2021). Cinnamaldehyde promotes intestinal barrier functions and reshapes gut microbiome in early-weaned rats. Frontiers in Nutrition, 8, 748503. https://doi.org/10.3389/fnut.2021.748503
Rajeswara Rao, B. R., Rajput, D. K., & Bhattacharya, A. K. (2007). Essential oil composition of petiole of Cinnamomum verum Bercht. & Presl. Journal of Spices and Aromatic Crops, 16(1), 38–41. https://www.researchgate.net/publication/269166602
Ranasinghe, P., Pigera, S., Premakumara, G. A. S., Galappaththy, P., Constantine, G. R., & Katulanda, P. (2013). Medicinal properties of “true” cinnamon (Cinnamomum zeylanicum): A systematic review. BMC Complementary and Alternative Medicine, 13, 275. https://doi.org/10.1186/1472-6882-13-275
Rao, P. V., & Gan, S. H. (2014). Cinnamon: A multifaceted medicinal plant. Evidence-Based Complementary and Alternative Medicine, 2014, 642942. https://doi.org/10.1155/2014/642942
Ravindran, P. N., Nirmal‑Babu, K., & Shylaja, M. (Eds.). (2003). Cinnamon and cassia: The genus Cinnamomum (1st ed.). CRC Press, Boca Raton. https://doi.org/10.1201/9780203590874
Rawat, I., Verma, N., & Joshi, K. (2020). Cinnamon (Cinnamomum zeylanicum). In: Medicinal plants in India: Importance and cultivation (pp. 164–177). Jaya Publishing House, New Delhi.
Ribeiro, P. R. E., Montero, I. F., Saravia, S. A. M., Ferraz, V. P., Santos, R. A., Marcía, J. A. F., & Linhares, B. M. (2020). Chemical composition and antioxidant activity in the essential oil of Cinnamomum zeylanicum Nees with medicinal interest. Journal of Medicinal Plants Research, 14(7), 326–330. https://doi.org/10.5897/JMPR2020.6966
Roșian, S., Boarescu, I., & Boarescu, P.-M. (2025). Antioxidant and anti-inflammatory effects of bioactive compounds in atherosclerosis. International Journal of Molecular Sciences, 26(3), 1379. https://doi.org/10.3390/ijms26031379
Sadeghi, S., Davoodvandi, A., Pourhanifeh, M. H., Sharifi, N., ArefNezhad, R., Sahebnasagh, R., Moghadam, S. A., Sahebkar, A., & Mirzaei, H. (2019). Anti-cancer effects of cinnamon: Insights into its apoptosis effects. European Journal of Medicinal Chemistry, 178, 131–140. https://doi.org/10.1016/j.ejmech.2019.05.067
Saeed, M., Kamboh, A. A., Syed, S. F., Babazadeh, D., Suheryani, I., Shah, Q. A., Umar, M., Kakar, I., Naveed, M., & Abd El‑Hack, M. E. (2018). Phytochemistry and beneficial impacts of cinnamon (Cinnamomum zeylanicum) as a dietary supplement in poultry diets. World’s Poultry Science Journal, 74(2), 331–346. https://doi.org/10.1017/S0043933918000235
Salama, M. A. M., Mostafa, N. E., Abd El‑Aal, N. F., Moawad, H. S. F., Hammad, S. K., Adel, R., & Mostafa, E. M. (2021). Efficacy of Zingiber officinale and Cinnamomum zeylanicum extracts against experimental Trichinella spiralis infection. Journal of Parasitic Diseases, 46(1), 24–36. https://doi.org/10.1007/s12639-021-01412-y
Sambaiah, K., & Srinivasan, K. (1991). Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Die Nahrung, 35(1), 47–51. https://doi.org/10.1002/food.19910350112
Santos, H. O., & da Silva, G. A. R. (2018). To what extent does cinnamon administration improve the glycemic and lipid profiles? Clinical Nutrition ESPEN, 27, 1–9. https://doi.org/10.1016/j.clnesp.2018.07.011
Scachetti, G., Person, O. C., Soares, B. G., Porpino, R., Bogar, P., & Angélico Júnio, F. V. (2020). Effectiveness of cinnamon bark extract in the treatment of allergic rhinitis. Revista Brasileira de Saúde Global, 1(1), 57.
Schink, A., Naumoska, K., Kitanovski, Z., Kampf, C. J., Fröhlich‑Nowoisky, J., Thines, E., Pöschl, U., Schuppan, D., & Lucas, K. (2018). Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways. Food & Function, 9, 5950–5964.
Senanayake, U. M., Lee, T. H., & Willis, R. B. H. (1978). Volatile constituents of cinnamon (Cinnamomum zeylanicum Blume). Journal of Agricultural and Food Chemistry, 26, 822–824. https://doi.org/10.1021/jf60218a031
Senderski, M. E. (2015). Prawie wszystko o ziołach i ziołolecznictwie. Wydawnictwo Mateusz E. Senderski.
Shanmugam, K., Sellappan, S., Alahmadi, T. A., Almoallim, H. S., Natarajan, N., & Veeraraghavan, V. P. (2022). Green synthesized zinc oxide nanoparticles from Cinnamomum verum bark extract inhibited cell growth and induced caspase-mediated apoptosis in oral cancer KB cells. Journal of Drug Delivery Science and Technology, 74, 103577. https://doi.org/10.1016/j.jddst.2022.103577
Shen, Y., Jia, L. N., Honma, N., Hosono, T., Ariga, T., & Seki, R. (2012). Beneficial effects of cinnamon on the metabolic syndrome, inflammation, and pain, and mechanisms underlying these effects: A review. Journal of Traditional and Complementary Medicine, 2, 27–32. https://doi.org/10.1016/S2225-4110(16)30067-0
Singh, G., Maurya, S., DeLampasona, M. P., & Catalan, C. A. (2007). A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and Chemical Toxicology, 45(9), 1650–1661. https://doi.org/10.1016/j.fct.2007.02.031
Singh, N., Rao, A. S., Nandal, A., Kumar, S., Yadav, S. S., Ganaie, S. A., & Narasimhan, B. (2020). Phytochemical and pharmacological review of Cinnamomum verum J. Presl – A versatile spice used in food and nutrition. Food Chemistry, 127773. https://doi.org/10.1016/j.foodchem.2020.127773
Singh, R. T., & Shrivastava, V. (2015). In-vitro efficacy evaluation of ethanolic extract of Cinnamomum zeylanicum as a potential antimicrobial agent against clinical isolates. International Journal of Pharmaceutical Sciences and Research, 6(5), 2201–2204.
Song, F., Li, H., Sun, J., & Wang, S. (2013). Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. Journal of Ethnopharmacology, 150(1), 125–130. https://doi.org/10.1016/j.jep.2013.08.019
Song, Y., Yu, Q.‑F., Zhang, D., Chen, L.‑G., Tan, Y.‑H., Zhu, W., Su, H.‑L., Yao, X., Liu, C., & Corlett, R. T. (2024). New insights into the phylogenetic relationships within the Lauraceae from mitogenomes. BMC Biology, 22(1), 241. https://doi.org/10.1186/s12915-024-02040-7
Songjie, J., Zhao, B., Gao, Y., Xie, J., Han, H., Wu, Q., & Yang, D. (2024). Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin‑1/DCC‑UNC5B signal transduction. Frontiers in Pharmacology, 15, 1367806. https://doi.org/10.3389/fphar.2024.1367806
Spence, C. (2024). Cinnamon: The historic spice, medicinal uses, and flavour chemistry. International Journal of Gastronomy and Food Science, 35, 100858. https://doi.org/10.1016/j.ijgfs.2023.100858
Steels, E., Steels, E., Deshpande, P., Thakurdesai, P., Dighe, S., & Collet, T. (2019). A randomized, double‑blind placebo‑controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. Complementary Therapies in Medicine, 47, 102198. https://doi.org/10.1016/j.ctim.2019.102198
Szafer, W., & Kostyniuk, M. (1962). Zarys paleobotaniki. Państwowe Wydawnictwo Naukowe.
Sztaba, D. (2009). Barwa szafranu, aromat cynamonu, smak kaparów – właściwości lecznicze biblijnych przypraw. Farmacja Polska, 69(1), 29–32.
Trifan, A., Zengin, G., Brebu, M., Skalicka‑Woźniak, K., & Luca, S. V. (2021). Phytochemical characterization and evaluation of the antioxidant and anti‑enzymatic activity of five common spices: Focus on their essential oils and spent material extractives. Plants, 10(12), 2692. https://doi.org/10.3390/plants10122692
Tsai, K.‑D., Liu, Y.‑H., Chen, T.‑W., Yang, S.‑M., Cherng, J., Chou, K.‑S., & Cherng, J.‑M. (2016). Cuminaldehyde from Cinnamomum verum induces cell death through targeting topoisomerase 1 and 2 in human colorectal adenocarcinoma COLO 205 cells. Nutrients, 8(6), 318. https://doi.org/10.3390/nu8060318
Vallianou, N., Tsang, C., Taghizadeh, M., Davoodvandi, A., & Jafarnejad, S. (2019). Effect of cinnamon (Cinnamomum zeylanicum) supplementation on serum C-reactive protein concentrations: A meta‑analysis and systematic review. Complementary Therapies in Medicine, 42, 271–278. https://doi.org/10.1016/j.ctim.2018.12.005
Varadarajan, S., Narasimhan, M., Balaji, T. M., Chamundeeswari, D. P., & Sakthisekaran, D. (2020). In vitro anticancer effects of Cinnamomum verum J. Presl, cinnamaldehyde, 4‑hydroxycinnamic acid and eugenol on an oral squamous cell carcinoma cell line. The Journal of Contemporary Dental Practice, 21(9), 1027–1033. https://doi.org/10.5005/jp-journals-10024-2922
Vivas, A. P., & Migliari, D. A. (2015). Cinnamon-induced Oral Mucosal Contact Reaction. The open dentistry journal, 9, 257–259. https://doi.org/10.2174/1874210601509010257
Walanj, S., Walanj, A. P., Mohan, V., & Thakurdesai, P. A. (2014). Efficacy and safety of the topical use of intranasal cinnamon bark extract in seasonal allergic rhinitis patients: A double-blind placebo-controlled pilot study. Journal of Herbal Medicine, 4(1), 37–47. https://doi.org/10.1016/j.hermed.2013.12.002
Wang, J., Wang, S., Yang, J., Henning, S. M., Ezzat‑Zadeh, A., Woo, S. L., Qin, T., Pan, Y., Tseng, C. H., Heber, D., & Li, Z. (2020). Acute effects of cinnamon spice on post‑prandial glucose and insulin in normal weight and overweight/obese subjects: A pilot study. Frontiers in Nutrition, 7, 619782. https://doi.org/10.3389/fnut.2020.619782
Wang, R., Wang, R., & Yang, B. (2009). Extraction of essential oils from five cinnamon leaves and identification of their volatile compound compositions. Innovative Food Science & Emerging Technologies, 10(2), 289–292. https://doi.org/10.1016/j.ifset.2008.12.004
Widya, A. W., & Ainatun, N. A. (2017). The investigation of cytotoxic effect of Cinnamomum zeylanicum extracts on human breast cancer cell line (MCF‑7). Science Heritage Journal, 1(2), 23–28. https://doi.org/10.26480/gws.02.2017.23.28
Williams, A. R., Ramsay, A., Hansen, T. V. A., Ropiak, H. M., Mejer, H., Nejsum, P., Mueller-Harvey, I., & Thamsborg, S. M. (2015). Anthelmintic activity of trans‑cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum). Scientific Reports, 5, 14791. https://doi.org/10.1038/srep14791
Wong, Y. C., Ahmad-Mudzaqqir, M. Y., & Wan‑Nurdiyana, W. A. (2014). Extraction of essential oil from cinnamon (Cinnamomum zeylanicum). Oriental Journal of Chemistry, 30(1), 37–47. https://doi.org/10.13005/ojc/300105
Wu, H. C., Horng, C. T., Lee, Y. L., Chen, P. N., Lin, C. Y., Liao, C. Y., Hsieh, Y. S., & Chu, S. C. (2018). Cinnamomum Cassia Extracts Suppress Human Lung Cancer Cells Invasion by Reducing u-PA/MMP Expression through the FAK to ERK Pathways. International journal of medical sciences, 15(2), 115–123. https://doi.org/10.7150/ijms.22293
Xiao, T. W., & Ge, X. J. (2022). Plastome structure, phylogenomics, and divergence times of tribe Cinnamomeae (Lauraceae). BMC Genomics, 23(1), 642. https://doi.org/10.1186/s12864-022-08855-4
Xue, Y. L., Shi, H. X., Murad, F., & Bian, K. (2011). Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vascular Health and Risk Management, 7, 273–280. https://doi.org/10.2147/VHRM.S15429
Yadav, A., Gupta, A., & Maurya, J. K. (2023). A review on cinnamon with their varieties and pharmacological action. International Journal of Novel Research and Development, 8(12), c881-c888. https://ijnrd.org/papers/IJNRD2312286.pdf
Yanakiev, S. (2020). Effects of cinnamon (Cinnamomum spp.) in dentistry: A review. Molecules, 25(18), 4184. https://doi.org/10.3390/molecules25184184
Yang, F., Long, E., Wen, J., Cao, L., Zhu, C., Hu, H., Ruan, Y., Okanurak, K., Hu, H., Wei, X., Yang, X., Wang, C., Zhang, L., Wang, X., Ji, P., Zheng, H., Wu, Z., & Lv, Z. (2014). Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum. Parasites & vectors, 7, 407. https://doi.org/10.1186/1756-3305-7-407
Yang, S. M., Tsai, K. D., Wong, H. Y., Liu, Y. H., Chen, T. W., Cherng, J., Hsu, K. C., Ang, Y. U., & Cherng, J. M. (2016). Molecular Mechanism of Cinnamomum verum Component Cuminaldehyde Inhibits Cell Growth and Induces Cell Death in Human Lung Squamous Cell Carcinoma NCI-H520 Cells In Vitro and In Vivo. Journal of Cancer, 7(3), 251–261. https://doi.org/10.7150/jca.13689
Youn, H. S., Lee, J. K., Choi, Y. J., Saitoh, S. I., Miyake, K., Hwang, D. H., & Lee, J. Y. (2008). Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochemical pharmacology, 75(2), 494–502. https://doi.org/10.1016/j.bcp.2007.08.033
Yu, L., Huang, C., Yang, W., Ren, Z., Li, L., Cheng, H., Lin, C., Zhai, L., Ning, Z., Wong, H. X., Han, Q., Jia, W., Bian, Z., & Zhao, L. (2023). Aqueous cinnamon extract ameliorates bowel dysfunction and enteric 5-HT synthesis in IBS rats. Frontiers in pharmacology, 13, 1010484. https://doi.org/10.3389/fphar.2022.1010484
Yu, T., Lee, S., Yang, W. S., Jang, H.-J., Lee, Y. J., Kim, T. W., Kim, S. Y., Lee, J., & Cho, J. Y. (2012). The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action. Journal of Ethnopharmacology, 139(2), 566–573. https://doi.org/10.1016/j.jep.2011.11.051
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