LEVEL OF ALDEHYDIC AND KETONIC DERIVATIVES OF OXIDATIVELY MODIFIED PROTEINS IN THE BLOOD OF MEN AND WOMEN WITH MYOCARDIAL INFARCTIONS AND HYPOTHYROIDISM

Abstract

Oxidative stress and excessive reactive oxygen species production play considerable roles in infarction-induced injury impairing cardiac functions, as well as thyroid diseases.

Purpose: assessment of the oxidative stress markers, including oxidation of proteins [concentrations of aldehydic and ketonic derivatives of oxidatively modified proteins (OMB)] in the blood of individuals with hypothyroidism and/or myocardial infarction living in the Central Pomerania.

Methodology. The level of oxidative stress markers was assessed among 225 individuals, i.e. 132 males (58.67%) and 93 females (41.33%) aged 35-71 years residing in Central Pomerania. In the obtained plasma, an assessment of levels of aldehydic and ketonic derivatives of oxidatively modified protein analyses was carried out.

Scientific novelty. The highest level of aldehydic and ketonic derivatives of oxidatively modified proteins was found in the group of males with myocardium infarctions and hypothyroidism compared to other groups. In females, an increase in aldehydic and ketonic derivatives was observed in the group with myocardial infarctions and in the group with hypothyroidism compared to the control group, while a decrease in aldehydic and ketonic derivatives was observed in subjects with myocardial infarction compared to individuals both with myocardial infarctions and hypothyroidism. In males, an increase in aldehydic and ketonic derivatives in both groups with myocardial infarctions and with hypothyroidism compared to the control group was observed, while in relation to the individuals with myocardial infarctions and hypothyroidism there was a decrease in aldehydic and ketonic derivatives in the group with myocardial infarctions and a decrease in ketonic derivatives in individuals with hypothyroidism. In addition, a decrease in the level of ketonic derivatives in the males with myocardial infarction and hypothyroidism compared to the group of females was observed.

Conclusions. In the course of myocardial infarction, gender affects the level of the aldehydic derivatives of oxidative modification of proteins.  Among individuals with hypothyroidism, the increase of ketonic derivatives of oxidatively modified proteins is also affected by sex. Analysis of oxidative stress markers depending on the sex may provide a biochemical basis for epidemiological differences in susceptibility to disease between sexes and suggest different strategies for risk assessment, diagnosis, and treatment specifically targeted at groups of males and females of different ages.