LIPID PEROXIDATION IN THE BLOOD OF MALES AND FEMALES WITH MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2

Abstract

Individuals with diabetes have a four-fold risk of developing coronary heart disease than those without diabetes. Dyslipidemia and hypertension associated with diabetes are additional risk factors for heart attack and myocardial infarctions. Oxidative stress induces many chronic diseases, especially diabetes and heart disease.

Purpose: determination of lipid peroxidation markers in males and females with type 2 diabetes, individuals who have had myocardial infarctions, and individuals with type 2 diabetes and myocardial infarctions compared with healthy individuals.

Methodology. The criteria for inclusion in the study were individuals with type 2 diabetes with a duration of at least 10 years, individuals with type 2 diabetes who had at least two myocardial infarcts, and healthy individuals (the control group of different genders), aged 35-71. In the obtained plasma, the level of lipid peroxidation (concentration of 2-thiobarbituric acid reacting substances) was assessed.

Scientific novelty. Our study showed a significant increase in lipid peroxidation biomarker levels in all subjects compared to the control group. Males had a higher level of lipid peroxidation compared to females, indicating that men with type 2 diabetes and/or myocardial infarctions were more exposed to the harmful effects of oxidative stress. An increase in lipid peroxidation markers in the plasma of individuals with myocardial infarctions and diabetes compared to healthy individuals was observed. This may indicate the key importance of oxidative stress in the pathology of diabetes and myocardial infarctions. Analysis of multifactorial variance among a group with type 2 diabetes and myocardial infarction has shown the increase in the level of lipid peroxidation markers is influenced by the male gender.

Conclusions. Increased plasma level of oxidative stress biomarkers was observed in both groups with myocardial infarctions and type 2 diabetes, as well as with diabetes and myocardial infarctions compared to the control group. In addition, a greater increase in lipid peroxidation in males compared to the female group was observed. The results obtained are another step in understanding the metabolic alterations in diabetes and myocardial infarction.