RED CELL INDICES IN MEN AND WOMEN WITH NORMAL AND LOW PLASMA IRON LEVELS
DOI:
https://doi.org/10.58407/bht.3.23.7Keywords:
iron concentration, erythrocyte count, hematocrit, hemoglobin, erythrocyte indicesAbstract
The aim of this study was to analyze changes in morphological blood parameters in women and men with reduced and normal iron levels. In this study, morphological blood parameters such as the count of red blood cells (RBC), hemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW) were studied in four groups of individuals (women with normal iron levels; women with reduced iron levels; men with normal iron levels; men with reduced iron levels).
Methodology. This study was carried out in a group of 203 individuals. The group of women participating in the study consisted of 106 individuals (52.2 %), while the group of men consisted of 97 individuals (47.8 %). After analysis of plasma iron levels, all patients were divided into the following groups: 1) women with normal iron levels (37-145 µg/dl, n = 48); 2) women with reduced iron levels (< 37 µg/dl; n = 58); 3) men with normal iron levels (59-158 µg/dl, n = 41); 4) men with reduced iron levels (< 59 µg/dl, n = 56). In each group of individuals, the number of erythrocytes and erythrocyte parameters was determined. Plasma iron was assessed using a substrate method. Hematological measurements were made in fresh venous blood. Hematology parameters were determined on an ABX Pentra DF120 hematology analyzer (Horiba ABX).
Scientific novelty. Erythrocyte indices analyzed in the blood of women with reduced iron levels compared to women with normal iron levels showed lower values of hemoglobin, hematocrit, MCV, MCH, and MCHC in the blood. Increased values of RDW and the count of erythrocytes in the blood of women with reduced iron levels compared to the control group of women were noted. Similarly, when comparing the values of erythrocyte indices obtained in the group of men with reduced iron levels to the control group of men with normal iron levels, reduced values of MCH, MCV, and MCHC were demonstrated. However, the values of the count of erythrocytes, RDW, hematocrit, and hemoglobin levels were elevated compared to the control. The reverse trend in erythrocyte indices such as hemoglobin and hematocrit indices between the group of women and the group of men with reduced iron levels was observed. Comparing the obtained values with the reference values, it was noted that the reduced values of the count of erythrocytes, and the level of hemoglobin and hematocrit were obtained in all study groups. An increased MCV value compared to the reference values was noted in the group of women and men with normal iron levels. Men with normal iron levels had elevated MCH values. In all studied groups, an increased level of RDW was noted compared to reference values.
Conclusions. Erythrocyte count, hemoglobin concentration, and certain erythrocyte indices (MCV, MCH, MCHC, and RDW) can be additional indices in the diagnosis of iron deficiency state both in men and women. It should be emphasized that even in non-anemic patients with erythrocyte count, hemoglobin concentration, and MCV, MCH, and MCHC above the lower limit of normal, the concentration of iron in the plasma could be lower than the reference values.
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