THE INFLUENCE OF PHYSICAL ACTIVITY, SMOKING, MYOCARDIAL INFARCTION AND DIABETES IN FAMILY HISTORY ON THE LEVEL OF LIPID PEROXIDATION MARKERS IN THE BLOOD OF WOMEN AND MEN WITH MYOCARDIAL INFARCTION AND TYPE 2 DIABETES
DOI:
https://doi.org/10.58407/bht.3.23.8Keywords:
myocardial infarction, type 2 diabetes, lipid peroxidation, 2-thiobarbituric acid reactive substances (TBARS), females, males, physical activity, smokingAbstract
Oxidative stress is associated with many chronic diseases, especially diabetes and heart disease. So far, many studies have focused on evaluating the various relations between oxidative stress and diabetes and cardiovascular diseases separately, but few studies are looking at both diseases simultaneously. The impact of lifestyle on oxidative stress in individuals with diabetes-related cardiovascular diseases is also still unclear.
Purpose: Paying attention to the actuality of the issue, the objective of our study was to assess the relationship between the levels of oxidative stress markers in individuals with multiple myocardial infarctions and type 2 diabetes, depending on physical activity, smoking, and the presence of myocardial infarctions and diabetes in the family anamnesis.
Methodology. The criteria for inclusion in the study were individuals with type 2 diabetes with a duration of at least 10 years, individuals with type 2 diabetes who had at least two myocardial infarcts, and healthy individuals (the control group of different genders), aged 35-71 years old. In the collected venous blood, the level of lipid peroxidation (concentration of 2-thiobarbituric acid reacting substances) was assessed.
Scientific novelty. Assessing changes in the levels of oxidative stress markers, i.e. lipid peroxidation (TBARS), in the blood of individuals of different gender and ages with myocardial infarcts, type 2 diabetes, as well as type 2 diabetes and myocardial infarcts and depending on lifestyle, we observed a significant increase in the TBARS levels in both individuals with type 2 diabetes, myocardial infarcts, as well as type 2 diabetes and myocardial infarcts. Our research showed that the level of lipid peroxidation increased regardless of the level of physical activity, both in individuals with myocardial infarcts, type 2 diabetes, as well as myocardial infarcts and type 2 diabetes.
Conclusions. The level of lipid peroxidation was increased in individuals with myocardial infarcts, type 2 diabetes, and myocardial infarcts and type 2 diabetes, regardless of whether the individuals smoked cigarettes or not. The presence of myocardial infarcts in the family may be a factor that affects the level of lipid peroxidation in individuals with diabetes and individuals with both myocardial infarcts and type 2 diabetes. The presence of diabetes in the family may be an additional factor in generating oxidative stress in type 2 diabetes.
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