ANTIMICROBIAL AND ANTICORROSIVE ACTIVITIES OF QUATERNARY QUINOLINIUM AND IMIDAZO[1,2-а] QUINOLINIUM SALTS
DOI:
https://doi.org/10.58407/bht.2.26.9Keywords:
sulfate-reducing bacteria, strain Desulfovibrio sp. M-4.1, quaternary quinolinium and imidazoquinolinium salts, microbial corrosion of steelAbstract
Purpose of the work. The aim of this study was to investigate the antimicrobial and anticorrosive activities of quaternary quinolinium and imidazo[1,2-a]quinolinium salts under conditions of microbial steel corrosion induced by sulfate-reducing bacteria Desulfovibrio sp.
Methodology. An experimental study of the antimicrobial and anticorrosive activities of quaternary quinolinium and imidazo[1,2-a]quinolinium salts was performed using conventional microbiological and corrosion methods. The biocidal activity of quinolinium and imidazoquinolinium bromide derivatives against strain Desulfovibrio sp. M-4.1 was determined. Furthermore, the inhibitory properties of quaternary imidazo[1,2-a]quinolinium salts under conditions of microbial steel corrosion were investigated. The antimicrobial and anticorrosive activities were evaluated taking into account the molecular structure of the quaternary salts.
Scientific novelty. A comparative study of the antimicrobial properties of a series of quinolinium and imidazo[1,2-a]quinolinium bromide derivatives has been conducted for the first time. The nature and position of the substituents in the phenyl fragment of the molecules of the studied heterocyclic systems significantly affect their antibacterial activity. It has been established that the annulation of the imidazole ring to the quinoline nucleus significantly enhances the antimicrobial and anticorrosive activity of the compounds. Quaternary imidazo[1,2-a]quinolinium salts exhibit simultaneous biocidal and inhibitory effects under conditions of microbial corrosion of steel.
Conclusions. Quaternary quinolinium and imidazo[1,2-a]quinolinium salts exhibit antimicrobial activity against sulfate-reducing bacteria Desulfovibrio sp. The biocidal effect of quinolinium salts is determined by the electronic nature of the substituent in the phenacyl fragment: the introduction of electron-withdrawing groups increases the inhibition of bacteria. Annulation of the imidazole ring to the quinoline nucleus (quaternary imidazo[1,2-a]quinolinium salts) leads to enhanced antimicrobial activity. Quaternary imidazoquinolinium salts exhibit high anticorrosive activity (protective effect is up to 92.4 %). This allows recommending the substances of this series as highly effective inhibitors with biocidal action for protecting steel from microbial corrosion.
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